Overview
- Inhibits conversion of levodopa to dopamine by Aromatic L-Amino Acid Decarboxylase in the periphery - does not pass blood brain barrier;
- Peripheral L-dopa decarboxylase is saturated by carbidopa at approximately 70 to 100mg a day, which reduces N/V due to peripheral conversion of L-dopa to dopamine [RXLIST-Sinemet];
- Dosing of carbidopa is constant, but amount of levodopa varies;