Elevated urinary levels of 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA)
and other markers of dysbiotic overgrowth with
Clostridium spp. are common in schizophrenia [GP2008], and
treating such individuals with antibiotics such as vancomycin can give
remission of symptoms without the use of neuroleptic drugs [Shaw2008].
Some practitioners have noted an association
between hypothyroidism and schizophrenia
(as well as schizoid and affective psychoses); treatment of
hypothyroidism appears to also rapidly (2 weeks) resolve schizophrenia
[DeGroot1996], [Zondek1944b], [Starr2005, pg 124].
Some practitioners have noted an association with
inflammatory process mediated by homocysteine [Rogers2008, pg 9]. Note that the common
diuretic hydrochlorothiazide (HCTZ) increases homocysteine levels [Westphal2003 🕮 ].