Please see conventional, complementary, and alternative medical treatments for important background information regarding the different types of medical treatments discussed on this page. Naturopathic, Complementary, and Alternative treatments that may be considered include:
According to [Younger2014 🕮 ], CRPS is a neuroinflammatory disease that LDN has been shown to benefit. [Toljan2018 🕮 ] summarizes cases of LDN being applied to intractable CRPS and achieving complete remission in some cases. [Brown2023 🕮 ] further reports a case series of 70 pain patients having various diagnoses which showed a positive response in 64% of the cases. 51% of the responders had a diagnosis of neuropathic pain or CRPS.
the Low Dose Naltrexone home page [LDN] suggests that this neuroinflammatory disease may be associated with autoimmune processes.
The mechanism of action of LDN in treating CRPS appears to be via Toll-like receptor 4 antagonism and/or opioid growth factor antagonism [Toljan2018 🕮 ].
Dr. Weyrich has been trained to use Low Dose Naltrexone (LDN). However, Dr. Weyrich has not treated any cases of Complex Regional Pain Syndrome (CRPS) with LDN.
Please see What is Low Dose Naltrexone? for more information.